Platelets are primary hemostasis via activating vWF, adhesive to collagen, releasing chemical messenger for the thrombotic process, a platelet plug function. However, there are 6 types of triggers of the platelet aggregations, and the antiplatelet therapy is geared toward these triggers. Medication therapies include Aspirin, ADP antagonists, PDE inhibitors, Glycoprotein IIB/IIIA receptor antagonists. Aspirin will permanently bind to the COX activated site; this will prevent the production to TXA2. Aspirin will render the platelet permanently inactive. Other medications therapies are also effective by inhibiting the platelet’s chemical signals.